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| Status |
Public on Mar 19, 2013 |
| Title |
The E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Analysis of gene expression altered upon knockdown of Siah2 in prosate cancer cells. The objective is to elucidate which signaling pathways or transcription factors are regulated by the E3 ubiquitin ligase Siah2 in human prostate cancer cells.
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| Overall design |
CWR22Rv1 cells were in fected with pLKO.1 control or Siah2 shRNA, and selected with 1ug/ml of puromycin to get stable transfectants. Total RNA was extracted for micorarray analysis to compare the diffentially expressed genes between pLKO.1 control and Siah2 knockdown cells.
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| Contributor(s) |
Qi J, Tripathi M, Sahgal N, Ettinger S, Placzek WJ, Claps G, Chung LK, Bowtel D, Gleave M, Bhowmick N, Ronai ZA |
| Citation(s) |
23518348 |
| |
| Submission date |
Jun 21, 2012 |
| Last update date |
Aug 13, 2018 |
| Contact name |
Natasha Sahgal |
| Organization name |
University of Oxford
|
| Department |
Ludwig Institute of Cancer Research
|
| Street address |
Old Road Campus
|
| City |
Oxford |
| ZIP/Postal code |
OX3 7DQ |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA169149 |
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