 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Dec 01, 2013 |
| Title |
Gene expression signatures of Meis1 conditional knockout hematopoietic stem cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Meis1 encodes a TALE family homeodomain protein that was first identified as a common retroviral integration site in mouse BHX2 myeloid leukemia. It functions as a DNA binding co-factor of Hox proteins through interacting with Pbx, a member of another TALE family protein. Moreover, Meis1 homozygous knockout mice are embryonic lethal, showing significant defects in vasculogenesis, eye development and hematopoiesis. Severe defects were also observed in adult hematopoiesis by conditional inactivation of Meis1 in vivo. Meis1 is critical to maintain the balance between enter and exit from cell cycles of hematopoietic stem cells (HSCs), indicating that Meis1 regulates self-renewal and quiescence of HSCs.
|
| |
|
| Overall design |
Total RNA was isolated from KSL cells obtained from poly(I:C)-treated Mx1-Cre Meis1fl/fl and sham-treated Meis1fl/fl mice.
|
| |
|
| Contributor(s) |
Ariki R, Morikawa S, Hidano S, Nakatake M, Matsuzaki Y, Nakauchi H, Nakamura T, Goitsuka R |
| Citation(s) |
24498346 |
| |
| Submission date |
May 30, 2012 |
| Last update date |
May 10, 2018 |
| Contact name |
Takuro Nakamura |
| E-mail(s) |
[email protected]
|
| Phone |
81-3-3570-0462
|
| Organization name |
Japanese Foundation for Cancer Research
|
| Department |
The Cancer Institute
|
| Lab |
Carcinogenesis
|
| Street address |
3-8-31 Ariake, Koto-ku
|
| City |
Tokyo |
| ZIP/Postal code |
135-8550 |
| Country |
Japan |
| |
|
| Platforms (1) |
| GPL4134 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Feature Number version) |
|
| Samples (4)
|
|
| Relations |
| BioProject |
PRJNA167683 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE38336_RAW.tar |
42.8 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
|
|
|
|
 |
Less...
More...