|
| Status |
Public on Dec 07, 2012 |
| Title |
Leptin and the Placental Response to Maternal Food Restriction during Early Pregnancy |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Concentrations of leptin decline during food restriction. This study was designed to test the hypothesis that some of the effects of maternal food restriction on placental development are mediated by the loss of leptin.
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| |
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| Overall design |
Mice were randomized to 3 treatment groups on day 1.5 of pregnancy: (1) ad libitum fed (control) (2) 50% food restriction (restricted) (3) 50% food restriction with leptin replacement (1µg/g body weight/day) (leptin). On day 11.5 placentas were collected, and two placentas from each mother were pooled for microarray analysis.
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| |
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| Contributor(s) |
Schulz LC, Caesar G, Schlitt J |
| Citation(s) |
22993381 |
| |
| Submission date |
May 21, 2012 |
| Last update date |
Nov 01, 2017 |
| Contact name |
Laura Clamon Schulz |
| E-mail(s) |
[email protected]
|
| Organization name |
University of Missouri
|
| Department |
Obstetrics, Gynecology and Women's Health
|
| Street address |
1 Hospital Dr.
|
| City |
Columbia |
| State/province |
MO |
| ZIP/Postal code |
65212 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL11202 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version) |
|
| Samples (15)
|
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| Relations |
| BioProject |
PRJNA167201 |
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