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| Status |
Public on Mar 31, 2013 |
| Title |
New protein from an unexpected ligament |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
This study describes the discovery of the gene responsible for differentiation of stem cells into ligament tissue. This important finding may lead to the development of treatments for gonarthrosis, rupture of the cruciate ligament and periodontal ligament, and ossification of the posterior longitudinal ligament.
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| Overall design |
This study describes the discovery of the gene (A) responsible for differentiation of stem cells into ligament tissue. The transfection of this gene into mouse mesenchymal stem cells resulted in the formation of ligament-like connective tissue composed of parallel fibres. We performed microarray analysis of four samples: stem cells (sample1), ligament-like tissue from stem cells transfected with A (sample 4), ligament tissue from A-transgenic mice (sample 2) , and ligament tissue from wild type mice (sample 3).
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| Contributor(s) |
Tsuru M, Soejima T, Shiba N, Kimura K, Sato K, Toyama Y, Nagata K |
| Citation(s) |
23442027 |
| |
| Submission date |
Jan 23, 2012 |
| Last update date |
Nov 01, 2017 |
| Contact name |
Michiyo Tsuru |
| E-mail(s) |
[email protected]
|
| Phone |
81-942-31-7568
|
| Organization name |
Kurume Universuty
|
| Department |
Orthopardic Surgery
|
| Street address |
67 Asahimachi
|
| City |
Kurume |
| State/province |
Fukuoka |
| ZIP/Postal code |
830-0011 |
| Country |
Japan |
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| Platforms (1) |
| GPL11202 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA152843 |
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