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| Status |
Public on Mar 01, 2012 |
| Title |
Identification of molecular pathways involved in oxaliplatin-associated sinusoidal dilatation |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Oxaliplatin-based chemotherapy for colorectal liver metastases (CRLM) can result in vascular liver lesions such as sinusoidal dilatations. Physiopathology remains unclear and variability between patients suggests that there is individual susceptibility. A better understanding of the molecular mechanisms of oxaliplatin liver toxicity may allow to identification of biomarkers and adaptation of chemotherapy delivery.
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| Overall design |
non-tumor frozen liver samples were obtained from patients operated on for CRLM after an exclusive oxaliplatin-based chemotherapy. Gene-expression profiles were first analyzed by microarray on a selected population of 20 patients; 9 patients with severe sinusoidal dilatation (SD) after a short period of chemotherapy and 10 patients without any sinusoidal dilatation after a long period of chemotherapy. These were compared with a control group of 5 patients without any chemotherapy and lesions
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| Contributor(s) |
Seman M |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Sep 26, 2011 |
| Last update date |
Jul 26, 2018 |
| Contact name |
Florent Dumont |
| E-mail(s) |
[email protected]
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| Organization name |
Université Paris-Saclay
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| Street address |
17 avenue des sciences
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| City |
91400 Orsay |
| State/province |
Ile de France |
| ZIP/Postal code |
91400 |
| Country |
France |
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| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (24)
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| GSM801588 |
patient, SD grade 0, G006 |
| GSM801589 |
patient, SD grade 0, G007 |
| GSM801590 |
patient, SD grade 0, G008 |
| GSM801591 |
patient, SD grade 0, G009 |
| GSM801592 |
patient, SD grade 0, G010 |
| GSM801593 |
patient, SD grade 0, G011 |
| GSM801594 |
patient, SD grade 0, G012 |
| GSM801595 |
patient, SD grade3, G301 |
| GSM801596 |
patient, SD grade3, G302 |
| GSM801597 |
patient, SD grade3, G303 |
| GSM801599 |
patient, SD grade3, G305 |
| GSM801600 |
patient, SD grade3, G306 |
| GSM801601 |
patient, SD grade3, G307 |
| GSM801602 |
patient, SD grade3, G308 |
| GSM801603 |
patient, SD grade3, G309 |
| GSM801604 |
patient, SD grade3, G312 |
| GSM801605 |
Control, T1 |
| GSM801606 |
Control, T2 |
| GSM801607 |
Control, T3 |
| GSM801608 |
Control, T5 |
| GSM801609 |
Control, T6 |
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| Relations |
| BioProject |
PRJNA147963 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE32384_RAW.tar |
94.6 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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