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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Oct 31, 2011 |
| Title |
Gene Expression profiling of Myc-induced lymphomagenesis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
The ability of oncogenes to provoke cancer is harnessed by regulators that control cell proliferation or induce apoptosis, and bypass of these checkpoints is a hallmark of malignancies. Myc oncoproteins are overexpressed in ~70% of all cancers and induce numerous transcription targets that regulate cell growth, metabolism, and the ribosome machinery. We used the Eμ-Myc mouse model from which one can directly compare expression profiles of wild type versus Myc-expressing B220+ pre-malignant lymphocytes and also queried differences in gene expression that ensue following the neoplastic switch to lymphoma (Nilsson et al., 2005 - PMID:15894264 and Keller et al. 2010 - PMID:20598117).
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| Overall design |
Wild type and precancerous Eμ-Myc transgenic B cells (from 4-6 week old littermates), and lymphomas from 13 independent Eμ-Myc mice were investigated. These samples were used for subsequent RNA purification, labeling and hybridization to MOE430A Affymetrix arrays.
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| Contributor(s) |
Cleveland JL, Fallahi M, Nilsson J, Hall MA, Rounbehler RJ |
| Citation(s) |
15894264, 20598117, 22039435, 22863009 |
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| Submission date |
Sep 20, 2011 |
| Last update date |
Jan 08, 2019 |
| Contact name |
John Lamoine Cleveland |
| Organization name |
H. Lee Moffitt Cancer Center
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| Street address |
12902 USF Magnolia Drive
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| City |
Tampa |
| State/province |
FL |
| ZIP/Postal code |
33612 |
| Country |
USA |
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| Platforms (1) |
| GPL339 |
[MOE430A] Affymetrix Mouse Expression 430A Array |
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| Samples (22)
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| GSM798898 |
Wild Type B220+, biological replicate 1 |
| GSM798899 |
Wild Type B220+, biological replicate 2 |
| GSM798900 |
Wild Type B220+, biological replicate 3 |
| GSM798901 |
Wild Type B220+, biological replicate 4 |
| GSM798902 |
Premalignant Myc B lymphocytes, biological replicate 1 |
| GSM798903 |
Premalignant Myc B lymphocytes, biological replicate 2 |
| GSM798904 |
Premalignant Myc B lymphocytes, biological replicate 3 |
| GSM798905 |
Premalignant Myc B lymphocytes, biological replicate 4 |
| GSM798906 |
Premalignant Myc B lymphocytes, biological replicate 5 |
| GSM798907 |
Malignant Myc B lymphocytes, biological replicate 1 |
| GSM798908 |
Malignant Myc B lymphocytes, biological replicate 2 |
| GSM798909 |
Malignant Myc B lymphocytes, biological replicate 3 |
| GSM798910 |
Malignant Myc B lymphocytes, biological replicate 4 |
| GSM798911 |
Malignant Myc B lymphocytes, biological replicate 5 |
| GSM798912 |
Malignant Myc B lymphocytes, biological replicate 6 |
| GSM798913 |
Malignant Myc B lymphocytes, biological replicate 7 |
| GSM798914 |
Malignant Myc B lymphocytes, biological replicate 8 |
| GSM798915 |
Malignant Myc B lymphocytes, biological replicate 9 |
| GSM798916 |
Malignant Myc B lymphocytes, biological replicate 10 |
| GSM798917 |
Malignant Myc B lymphocytes, biological replicate 11 |
| GSM798918 |
Malignant Myc B lymphocytes, biological replicate 12 |
| GSM798919 |
Malignant Myc B lymphocytes, biological replicate 13 |
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| Relations |
| BioProject |
PRJNA147195 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE32239_RAW.tar |
62.4 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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