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| Status |
Public on Jan 30, 2012 |
| Title |
Post-therapeutic relapse of psoriasis associated with CD11a blockade is associated with T cells and inflammatory myeloid DCs |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
To understand the development of new psoriasis lesions, we studied a group of moderate-to-severe psoriasis patients who experienced a relapse after ceasing efalizumab (anti-CD11a, Raptiva, Genentech). There were increased CD3+ T cells, neutrophils, CD11c+ and CD83+ myeloid DCs, but no increase in CD1c+ resident myeloid DCs. In relapsed lesions, there were many CD11c+CD1c-, inflammatory myeloid DCs identified by TNFSF10/TRAIL, TNF, and iNOS. CD11c+ cells in relapsed lesions co-expressed CD14 and CD16 in situ. Efalizumab induced an improvement in many psoriasis genes, and during relapse, the majority of these genes reversed back to a lesional state. Gene Set Enrichment Analysis (GSEA) of the transcriptome of relapsed tissue showed that many of the gene sets known to be present in psoriasis were also highly enriched in relapse. Hence, on ceasing efalizumab, T cells and myeloid cells rapidly enter the skin to cause classic psoriasis.
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| Overall design |
To determine the transcsriptome of skin samples in 4 responding patients who relapsed after receiving efalizumab for treatment of psoriasis, using paired baseline non-lesional (=NL, n=2); lesional (LS, n=4);week 12 post-treatment (week 12, n=4), and relapse (n=4).
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| Contributor(s) |
Suárez-Fariñas M, Lowes MA |
| Citation(s) |
22348003 |
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| Submission date |
Jul 19, 2011 |
| Last update date |
Dec 06, 2018 |
| Contact name |
Mayte Suarez-Farinas |
| E-mail(s) |
[email protected]
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| Organization name |
Mount SinaiSchool of Medicine
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| Street address |
1425 Madison Ave, L2-70C, Box 1077,
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| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10075 |
| Country |
USA |
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| Platforms (1) |
| GPL571 |
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array |
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| Samples (14)
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| Relations |
| BioProject |
PRJNA144339 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE30768_RAW.tar |
26.9 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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