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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jul 06, 2011 |
| Title |
Gene Expression Analysis of Transgenic Myc-Driven Liver Tumor Formation and Regression |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Gene expression changes were examined in transgenic MYC-driven liver cancers at different time points as tumors formed and upon early regression. Time points evaluated include: Control (non-tumor bearing), Pre-tumor (mice were removed from doxyclycine in their diet to induce MYC oncogene expression for 4-5 weeks), Tumor (tumor nodules from mice that had been off of doxycycline for 8-9 weeks) and Early tumor regression (tumor-bearing mice were placed back on doxycycline for 72 hrs to inhibit MYC oncogene expresion).
MYC-Driven Mouse Tumor Models are described in Schahaf, et al., Nature, 2004 and Goga, et al., Nature Medicine, 2007.
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| Overall design |
11 Total Samples: 3 Control, 4 Pre-Tumor, 4 Tumor, 4 Early Tumor Regression. Control = LAP-tTA transgenic mice. Others = TRE-MYC x LAP-tTA double transgenic mice (doxy off).
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| Contributor(s) |
Goga A, Balakrishnan A |
| Citation(s) |
21723511 |
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| Submission date |
Mar 28, 2011 |
| Last update date |
Jan 12, 2017 |
| Contact name |
Andrei Goga |
| E-mail(s) |
[email protected]
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| Organization name |
UCSF
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| Department |
Cell & Tissue Biology
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| Lab |
Goga Lab
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| Street address |
513 Parnassus Ave
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| City |
San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94143-0512 |
| Country |
USA |
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| Platforms (1) |
| GPL7202 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version) |
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| Samples (15)
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| Relations |
| BioProject |
PRJNA139633 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE28198_RAW.tar |
32.6 Mb |
(http)(custom) |
TAR (of TXT) |
| GSE28198_normalized_matrix.txt.gz |
3.9 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
| Processed data are available on Series record |
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