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| Status |
Public on Jul 29, 2024 |
| Title |
Profile of gene expression in murine tubular cells MCTs treated with the cytokine TWEAK |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Treatment of acute kidney injury (AKI) is suboptimal. TWEAK is known to mediate cell death and inflammation in AKI. Transcriptomic analysis of murine tubular cells will allow us to identify novel mediators and therapeutic targets of this pathology.
TWEAK is an inflammatory cytokine which is upregulated in AKI. Transcriptomic analysis of TWEAK-stimulated cultured murine tubular epithelial cells identified downregulation of peroxisome proliferator activated receptor-g coactivador-1a (PGC-1a) and its target genes (mitochondrial proteins Ndufs1, Sdha, and Tfam) as a shared feature.
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| Overall design |
MCT tubular cells were exposed to 100 ng/ml TWEAK for 6 h or vehicle (n = 3 independent experiments)
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| Contributor(s) |
Sanz AB, Ortiz A, Ramos AM, Sanchez-Niño MD |
| Citation(s) |
26535995 |
| |
| Submission date |
Jul 24, 2024 |
| Last update date |
Jul 30, 2024 |
| Contact name |
Ana Belen Sanz |
| E-mail(s) |
[email protected]
|
| Organization name |
IIS-Fundacion Jimenez Diaz
|
| Lab |
Experimental Nephrology
|
| Street address |
Avda. Reyes Catolicos 2
|
| City |
Madrid |
| ZIP/Postal code |
28040 |
| Country |
Spain |
| |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA1139856 |
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