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| Status |
Public on May 03, 2012 |
| Title |
Upregulation of pro-apoptotic microRNA mir-125a following massive small bowel resection in rats |
| Organism |
Rattus norvegicus |
| Experiment type |
Non-coding RNA profiling by array
|
| Summary |
Upregulation of mir-125a suppresses the pro-survival protein Mcl1, producing the increase in apoptosis known to accompany the proliferative changes characteristic of intestinal adaptation. Our data highlight a potential role for microRNAs as mediators of the adaptive process and may facilitate the development of new therapeutic options for short bowel syndrome.
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| |
|
| Overall design |
Two-condition experiment: resected rat jejunum vs. pooled transected control, with dye-swaps.
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| |
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| Contributor(s) |
Dreyfuss JM |
| Citation(s) |
22418008 |
| |
| Submission date |
Jan 11, 2011 |
| Last update date |
May 03, 2012 |
| Contact name |
Jonathan M Dreyfuss |
| Organization name |
Joslin Diabetes Center
|
| Department |
Bioinformatics & Biostatistics Core
|
| Street address |
1 Joslin Pl
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02215 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL10124 |
Exiqon miRCURY LNA microRNA array v.8.1 |
|
| Samples (5)
|
|
| Relations |
| BioProject |
PRJNA136619 |
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