|
| Status |
Public on Aug 31, 2011 |
| Title |
MYC drives resistance to PI3K/mTOR targeted inhibition (gene expression) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Gene expression signatures were measured after treatment of cells with 50nM BEZ235. Affymetrix HG-U133AV2 expression arrays were performed according to the manufacturer's directions using RNA extracted by Qiagen RNeasy from engineered human cell-lines grown for 72h in the presence of 50nM BEZ235
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| |
|
| Overall design |
Resulting expression signatures where derived based on phenotypic properties(resistance to BEZ235) of the cells (enriched vs GFP/HR).
|
| |
|
| Contributor(s) |
Ilic N, Roberts T |
| Citation(s) |
21876152 |
| |
| Submission date |
Nov 05, 2010 |
| Last update date |
Dec 06, 2018 |
| Contact name |
Nina Ilic |
| E-mail(s) |
[email protected]
|
| Phone |
617 632 6293
|
| Fax |
617 632 4770
|
| Organization name |
Dana-Farber Cancer Institute
|
| Department |
Cancer Biology
|
| Lab |
Roberts Laboratory-SM912
|
| Street address |
44 Binney Street
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02115 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL571 |
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array |
|
| Samples (9)
|
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| This SubSeries is part of SuperSeries: |
| GSE25173 |
PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis |
|
| Relations |
| BioProject |
PRJNA142801 |
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