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Series GSE246559 Query DataSets for GSE246559
Status Public on Oct 30, 2024
Title Methylomic signatures of tau and beta amyloid in transgenic mouse models of Alzheimer’s disease neuropathology [HorvathMammalMethylChip40 Methylation Beadchip]
Platform organisms Homo sapiens; Mus musculus; Rattus norvegicus
Sample organism Mus musculus
Experiment type Methylation profiling by array
Summary We identified widespread DNA methylation changes associated with the development of both tau and amyloid neuropathology, including differentially methylated positions (DMPs) and regions (DMRs) at loci previously implicated in AD and overlapping changes identified in our ongoing analyses of human post-mortem AD brains.
 
Overall design DNA was collected from mouse entorhinal cortex and hippocampus samples and methylation levels quantified using both array and RRBS technology. Array data was measured using the HorvathMammalMethylChip40 Methylation Beadchip on the Illumina platform.
 
Contributor(s) Castanho I, Walker E, Leung SK, Policicchio S, Seiler Vellame D, Harvey J, Baulf H, Dempster E, Shireby G, Moore K, Collier D, Ahmed Z, Hannon E, Mill J
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Submission date Oct 30, 2023
Last update date Oct 30, 2024
Contact name Emma Walker
E-mail(s) [email protected]
Organization name University of Exeter
Street address RILD Barrack Rd
City Exeter
ZIP/Postal code EX2 5DW
Country United Kingdom
 
Platforms (1)
GPL28271 Illumina HorvathMammalianMethylChip40 BeadChip
Samples (159)
GSM7871312 Cortex Entorhinalis_J20_WT [204027420024_R01C01]
GSM7871313 Cortex Entorhinalis_J20_WT [204027420024_R02C01]
GSM7871314 Cortex Entorhinalis_J20_TG [204027420024_R03C01]
This SubSeries is part of SuperSeries:
GSE246561 Methylomic signatures of tau and beta amyloid in transgenic mouse models of Alzheimer’s disease neuropathology
Relations
BioProject PRJNA1033635

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE246559_NormalisedBetaMatrix.csv.gz 29.2 Mb (ftp)(http) CSV
GSE246559_RAW.tar 119.0 Mb (http)(custom) TAR (of IDAT)

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