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Series GSE24186 Query DataSets for GSE24186
Status Public on Sep 05, 2011
Title Atorvastatin, rosuvastatin and rifampicin effect on human primary hepatocyte transcriptome [Steroltalk platform]
Organism Homo sapiens
Experiment type Expression profiling by array
Summary With particular emphasis on interactions between cholesterol homeostasis and drug metabolism we investigate the transcriptome of human primary hepatocytes treated by two commonly prescribed cholesterol lowering drugs atorvastatin and rosuvastatin and by rifampicin that serves as an outgroup as well as a model substance for induction of nuclear receptor PXR.
Expression profiling with dedicated Steroltalk cDNA arrays shows that statins induce extensive transcriptome changes.
 
Overall design 10 condition experiment: 3 treatments (atorvastatin, rifampicin, rosuvastatin), each measured at 3 time points (12, 24 and 48 hours), and untreated cells. 3-7 biological replicates for each treatment condition, 20 biological and technical replicates for untreated cells. Common reference design.
 
Contributor(s) Hafner M, Juvan P, Režen T, Rozman D
Citation(s) 21869732
Submission date Sep 17, 2010
Last update date Mar 22, 2012
Contact name Peter Juvan
Phone +386 1 543 7595
Organization name Faculty of Medicine, University of Ljubljana
Department Institute of Biochemistry
Lab Center for Functional Genomics and Bio-Chips
Street address Zaloska 4
City Ljubljana
ZIP/Postal code SI-1000
Country Slovenia
 
Platforms (1)
GPL8091 Steroltalk v2 human
Samples (71)
GSM594958 Atorvastatin 12h donor 089 [Steroltalk]
GSM594959 Atorvastatin 12h donor 270 [Steroltalk]
GSM594960 Atorvastatin 12h donor 272 [Steroltalk]
This SubSeries is part of SuperSeries:
GSE24188 Atorvastatin, rosuvastatin and rifampicin effect on human primary hepatocyte transcriptome
Relations
BioProject PRJNA133699

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE24186_RAW.tar 5.9 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table
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