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| Status |
Public on Sep 20, 2023 |
| Title |
Effect of EZH2 inhibition on NUT carcinoma gene expression over time |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To determine roughly the time point at which most transcriptional changes occur in response to tazemetostat (taz, aka EPZ-6438 (EPZ)) treatment of NUT carcinoma cells, we performed RNAseq over a time course.
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| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for PER-403 and 10-15 NUT carcinoma cells treated with taz for 36h, 72h, 96h, and 144h.
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| Web link |
https://pubmed.ncbi.nlm.nih.gov/37747726/
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| Contributor(s) |
French CA, Huang D |
| Citation(s) |
37747726 |
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| Submission date |
May 18, 2023 |
| Last update date |
Jan 04, 2024 |
| Contact name |
Chris A French |
| E-mail(s) |
[email protected]
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| Phone |
6175254415
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| Organization name |
BWH
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| Department |
Pathology
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| Street address |
75 francis st.
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| City |
boston |
| State/province |
MA |
| ZIP/Postal code |
02115 |
| Country |
USA |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (20)
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| GSM7384387 |
10-15,144h,1uM taz [S17] |
| GSM7384388 |
10-15,96h,1uM taz [S21] |
| GSM7384389 |
10-15,72h,1uM taz [S25] |
| GSM7384390 |
10-15,72h,DMSO [S29] |
| GSM7384391 |
10-15,36h,1uM taz [S30] |
| GSM7384392 |
10-15,96h,1uM taz [S5] |
| GSM7384393 |
10-15,72h,1uM taz [S9] |
| GSM7384394 |
PER-403,36h,1uM taz [PER-403 S1] |
| GSM7384395 |
PER-403,144h,1uM taz [PER-403 S13] |
| GSM7384396 |
PER-403,36h,1uM taz [PER-403 S17] |
| GSM7384397 |
PER-403,72h,1uM taz [PER-403 S20] |
| GSM7384398 |
PER-403,72h,DMSO [PER-403 S24] |
| GSM7384399 |
PER-403,96h,1uM taz [PER-403 S25] |
| GSM7384400 |
PER-403,144h,1uM taz [PER-403 S29] |
| GSM7384401 |
PER-403,72h,1uM taz [PER-403 S4] |
| GSM7384402 |
PER-403,72h,DMSO [PER-403 S8] |
| GSM7384403 |
PER-403,96h,1uM taz [PER-403 S9] |
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| Relations |
| BioProject |
PRJNA974050 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE232838_RAW.tar |
621.2 Mb |
(http)(custom) |
TAR (of TDF) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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