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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Feb 17, 2024 |
| Title |
Chromatin accessibility profile of splenic LCMV-specific memory B cells following type I or II interferon blockade in acute versus chronic LCMV infection |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
Dynamics of interferon signalling impact the adaptive immune response. We used ATAC sequencing (ATAC-seq) to analyze chromatin accessibility in memory B cells from mice infected with acute or chronic LCMV infection, treated with type I or type II interferon blocking antibodies.
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| Overall design |
Splenic LCMV-specific memory B cells from LCMV-infected mice were isolated by fluorescence-activated cell sortings (FACS) and analysed using ATAC-seq.
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| Contributor(s) |
Good-Jacobson KL, Cooper L, Scharer CD |
| Citation(s) |
38593796 |
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| Submission date |
Mar 02, 2023 |
| Last update date |
May 19, 2024 |
| Contact name |
Kim Good-Jacobson |
| E-mail(s) |
[email protected]
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| Organization name |
Monash University
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| Street address |
Gr Fl Reception (Bldg 77) 23 Innovation Walk
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| City |
Clayton |
| State/province |
Victoria |
| ZIP/Postal code |
3800 |
| Country |
Australia |
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| Platforms (1) |
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| Samples (16)
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| GSM7077833 |
LCMV-WE, D15, Control, replicate 1, ATAC-seq |
| GSM7077834 |
LCMV-WE, D15, Control, replicate 2, ATAC-seq |
| GSM7077835 |
LCMV-WE, D15, IFNAR1 block, replicate 1, ATAC-seq |
| GSM7077836 |
LCMV-WE, D15, IFNAR1 block, replicate 2, ATAC-seq |
| GSM7077837 |
LCMV-Docile, D15, Control, replicate 1, ATAC-seq |
| GSM7077838 |
LCMV-Docile, D15, Control, replicate 2, ATAC-seq |
| GSM7077839 |
LCMV-Docile, D15, IFNAR1 block, replicate 1, ATAC-seq |
| GSM7077840 |
LCMV-Docile, D15, IFNAR1 block, replicate 2, ATAC-seq |
| GSM7077841 |
LCMV-Docile, D15, IFNAR1 block, replicate 3, ATAC-seq |
| GSM7077842 |
LCMV-Docile, D41, Control, replicate 1, ATAC-seq |
| GSM7077843 |
LCMV-Docile, D41, Control, replicate 2, ATAC-seq |
| GSM7077844 |
LCMV-Docile, D41, IFNγ block, replicate 1, ATAC-seq |
| GSM7077845 |
LCMV-Docile, D41, IFNγ block, replicate 2, ATAC-seq |
| GSM7077846 |
LCMV-Docile, D41, IFNγ block, replicate 3, ATAC-seq |
| GSM7077847 |
LCMV-Docile, D41, IFNAR1 block, replicate 1, ATAC-seq |
| GSM7077848 |
LCMV-Docile, D41, IFNAR1 block, replicate 2, ATAC-seq |
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| Relations |
| BioProject |
PRJNA940424 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE226485_diff.glm.ATACseq.LCMV_IFN_MBC_ATAC.GEO.txt.gz |
25.1 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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