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| Status |
Public on Dec 31, 2023 |
| Title |
Intrinsic innate immunostimulation by small circRNA vaccines [tumor] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Various RNAs have been shown to elicit innate immunity by activating endosomal PRRs such as Toll-like receptors 3/7/8 (TLR3/7/8), and cytosolic PRRs (e.g., retinoic acid-inducible gene I (RIG-I), melanoma differentiation-associated protein 5 (MDA5)). Such innate immunity provides cytokines and co-stimulation signals that are essential for adaptive immunomodulation.
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| Overall design |
We further employed RNA-seq genome-wide transcriptome analysis for the comprehensive understanding of the immunomodulation mechanisms by small circRNA vaccines in BMDCs or tumor tissues.
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| Contributor(s) |
Zhang Y, Zhu G, Liu J, Tyc KM |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Dec 15, 2022 |
| Last update date |
Dec 31, 2023 |
| Contact name |
Guizhi Zhu |
| Organization name |
Virginia Commonwealth University
|
| Street address |
410 N 12th St
|
| City |
Richmond |
| State/province |
VA |
| ZIP/Postal code |
23298 |
| Country |
USA |
| |
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| Platforms (1) |
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| Samples (9)
|
| GSM6843182 |
tumor treated with circRNA replicate 1 |
| GSM6843183 |
tumor treated with circRNA replicate 2 |
| GSM6843184 |
tumor treated with circRNA replicate 3 |
| GSM6843185 |
tumor treated with circRNA + anti-PD-1 replicate 1 |
| GSM6843186 |
tumor treated with circRNA + anti-PD-1 replicate 2 |
| GSM6843187 |
tumor treated with circRNA + anti-PD-1 replicate 3 |
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| This SubSeries is part of SuperSeries: |
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| Relations |
| BioProject |
PRJNA912728 |
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