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| Status |
Public on Mar 29, 2023 |
| Title |
Transcriptome data of bone marrow long-term hematopoietic stem cells (LT-HSCs) from mice with or without 3-month high cholesterol diet (HCD) treatment |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The vulnerability of bone marrow hematopoiesis to perturbations of cholesterol metabolism is well documented, while the underlying cellular and molecular mechanisms remain poorly understood. Here we reveal a distinct cholesterol metabolic signature of hematopoietic stem cells (HSCs) within the hematopoietic compartment.To identify the phenotype switching and function variation in BM LT-HSCs with HCD treatment, we performed RNA-seq of LT-HSCs from the bone marrow of mice with or without3-month HCD treatment.
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| Overall design |
We then performed gene expression profiling analysis using data obtained from RNA-seq of BM LT-HSCs (Lin-c-Kit+Sca1+CD34-CD135-) from mice with or without 3-month HCD treatment.
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| Contributor(s) |
Liu C, Du C, Wang J |
| Citation(s) |
36906952 |
| |
| Submission date |
Sep 23, 2022 |
| Last update date |
Mar 30, 2023 |
| Contact name |
Chaonan Liu |
| E-mail(s) |
[email protected]
|
| Organization name |
the Army Medical University
|
| Street address |
Gaotanyan Street
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| City |
CHONGQING |
| ZIP/Postal code |
400000 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA883663 |
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