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GEO help: Mouse over screen elements for information. |
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| Status |
Public on May 25, 2023 |
| Title |
TXNRD1 drives innate immune response in senescent cells and promotes age-associated inflammation II |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Sterile inflammation, also known as “inflammaging”, is a hallmark of tissue ageing. Cellular senescence contributes to tissue aging in part through secretion of proinflammatory factors known as senescence-associated secretory phenotype (SASP). Thioredoxin reductase 1 (TXNRD1) genetic variability is associated with aging and age-associated phenotypes such as late-life survival, activity of daily living, and physical performance at old age. TXNRD1’s role in regulating tissue ageing has been attributed to its enzymatic role in reducing reactive oxygen species. Here we show that TXNRD1 drives SASP and inflammaging through the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) innate immune response pathway independent of its enzymatic activity
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| Overall design |
RNA-seq of Young and Aged mice, with Aged mice under control and TRi-1 or Auranofin treatment
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| Contributor(s) |
Zhang R, Hao X |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
May 25, 2022 |
| Last update date |
May 25, 2023 |
| Contact name |
Priyankara J Wickramasinghe |
| E-mail(s) |
[email protected]
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| Phone |
2154956837
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| Organization name |
The Wistar Institute
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| Department |
Bioinformatics
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| Lab |
Genomics
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| Street address |
3601 Spruce Street
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| City |
Philadelphia |
| State/province |
PA |
| ZIP/Postal code |
19104 |
| Country |
USA |
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| Platforms (1) |
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| Samples (27)
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| GSM6198680 |
experiment 1, Young mouse, untreated, replicate 1 |
| GSM6198681 |
experiment 1, Young mouse, untreated, replicate 2 |
| GSM6198682 |
experiment 1, Young mouse, untreated, replicate 3 |
| GSM6198683 |
experiment 1, Young mouse, untreated, replicate 4 |
| GSM6198684 |
experiment 1, Young mouse, untreated, replicate 5 |
| GSM6198685 |
experiment 1, Aged mouse, untreated, replicate 1 |
| GSM6198686 |
experiment 1, Aged mouse, untreated, replicate 2 |
| GSM6198687 |
experiment 1, Aged mouse, untreated, replicate 3 |
| GSM6198688 |
experiment 1, Aged mouse, untreated, replicate 4 |
| GSM6198689 |
experiment 1, Aged mouse, Treated treated, replicate 1 |
| GSM6198690 |
experiment 1, Aged mouse, Treated treated, replicate 2 |
| GSM6198691 |
experiment 1, Aged mouse, Treated treated, replicate 3 |
| GSM6198692 |
experiment 1, Aged mouse, Treated treated, replicate 4 |
| GSM6198693 |
experiment 2, Young mouse, untreated, replicate 1 |
| GSM6198694 |
experiment 2, Young mouse, untreated, replicate 2 |
| GSM6198695 |
experiment 2, Young mouse, untreated, replicate 3 |
| GSM6198696 |
experiment 2, Young mouse, untreated, replicate 4 |
| GSM6198697 |
experiment 2, Young mouse, untreated, replicate 5 |
| GSM6198698 |
experiment 2, Aged mouse, untreated, replicate 1 |
| GSM6198699 |
experiment 2, Aged mouse, untreated, replicate 2 |
| GSM6198700 |
experiment 2, Aged mouse, untreated, replicate 3 |
| GSM6198701 |
experiment 2, Aged mouse, untreated, replicate 4 |
| GSM6198702 |
experiment 2, Aged mouse, untreated, replicate 5 |
| GSM6198703 |
experiment 2, Aged mouse, Treated treated, replicate 1 |
| GSM6198704 |
experiment 2, Aged mouse, Treated treated, replicate 2 |
| GSM6198705 |
experiment 2, Aged mouse, Treated treated, replicate 3 |
| GSM6198706 |
experiment 2, Aged mouse, Treated treated, replicate 4 |
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| This SubSeries is part of SuperSeries: |
| GSE205206 |
TXNRD1 drives innate immune response in senescent cells and promotes age-associated inflammation |
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| Relations |
| BioProject |
PRJNA842434 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE204841_TXNRD1_RNAseq_invivo.txt.gz |
948.1 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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