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| Status |
Public on Jun 22, 2022 |
| Title |
Genomewide effects of regular caffeine intake on hippocampal metabolism and learning-dependent transcription [Cut & Tag] |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Caffeine is the most widely consumed psychoactive substance worldwide. Strikingly, molecular pathways engaged by its regular consumption remain unclear. We herein addressed the mechanisms associated with habitual (chronic) caffeine consumption in the mouse hippocampus using untargeted orthogonal-omics techniques. Our results revealed that chronic caffeine exerts concerted pleiotropic effects in the hippocampus, at the epigenomic, proteomic and metabolomic levels, lowered metabolic-related processes in bulk tissue, while inducing neuronal-specific epigenetic changes at synaptic transmission/neuronal activity-related genes. Altogether, these findings suggest that regular intake of caffeine improves the signal-to-noise ratio during information encoding in learning in part through a re-setting of metabolic genes helping to bolster the salience of information processing in neuronal circuits.
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| Overall design |
Cut & tag
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| |
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| Contributor(s) |
Blum D |
| Citation(s) |
35536645, 37960344 |
| |
| Submission date |
Apr 04, 2022 |
| Last update date |
Dec 06, 2023 |
| Contact name |
David Blum |
| E-mail(s) |
[email protected]
|
| Organization name |
Inserm
|
| Department |
Lille Neurosience & Cognition
|
| Lab |
Alzheimer & Tauopathies
|
| Street address |
1 place de Verdun
|
| City |
Lille |
| State/province |
Cedex |
| ZIP/Postal code |
59045 |
| Country |
France |
| |
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| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
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| Samples (14)
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| This SubSeries is part of SuperSeries: |
| GSE167123 |
Genomewide effects of regular caffeine intake on hippocampal metabolism and learning-dependent transcription |
|
| Relations |
| BioProject |
PRJNA823354 |
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