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| Status |
Public on Dec 28, 2021 |
| Title |
Small-Molecule-Driven Direct Reprogramming of Fibroblasts into functional Sertoli-like cells as a model for male reproductive toxicology |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We report the generation of functional Sertoli-like cells from mice fibroblasts using only chemical cocktails, I-bet151 and Riluzole (IR). CiSCs possess similar gene expression profiles and biological functions to endogenous Sertoli cells and are highly sensitive to reproductive toxicants.
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| Overall design |
A total of 6 samples（2 CiSCs, 2 MEFs, 2 MSCs） were tested using the BGISEQ platform for this project to prove that the CiSC resemble Sertoli cell in genome-wide gene expression profile.
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| Contributor(s) |
Li Q, Yang Y |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Dec 21, 2021 |
| Last update date |
Dec 29, 2021 |
| Contact name |
Quan Li |
| E-mail(s) |
[email protected]
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| Organization name |
Jinan University
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| Street address |
West Huangpu Avenue
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| City |
Guangzhou |
| State/province |
Guangdong |
| ZIP/Postal code |
510632 |
| Country |
China |
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| Platforms (1) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA791352 |
| SRA |
SRP351962 |
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