|
| Status |
Public on Apr 16, 2022 |
| Title |
Effects of S100A8 inhalation on expression of genes in the lung microenvironment |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by RT-PCR
|
| Summary |
Because S100A8 inhalation delayed lung tumor growth (LLC) in mice but did not directly affect tumor cell viability, we sought to determine potential changes in the lung microenviornment that contributed to its anti-tumor effects.
Effects of S100A8 treatment on the lung microenvironment were assessed using a panel of 98 genes that affect immune regulation, redox, cancer growth, metastasis, hypoxia and angiogenesis.
|
| |
|
| Overall design |
We averaged expression of each gene in lungs from 4-5 independent mice per treatment group. We compared gene expression in mice treated with S100A8+LLC, HBSS+LLC, S100A8+vehicle to HBSS+vehicle (control). In total, there were 4 samples.
|
| |
|
| Contributor(s) |
Wong SW, McCarroll J, Hsu K, Geczy CL, Tedla N |
| Citation(s) |
35655772 |
| |
| Submission date |
Dec 13, 2021 |
| Last update date |
Jun 21, 2022 |
| Contact name |
Sze Wing Wong |
| Organization name |
Children's Cancer Institute
|
| Street address |
PO Box 81 Randwick
|
| City |
Sydney |
| State/province |
NSW |
| ZIP/Postal code |
2031 |
| Country |
Australia |
| |
|
| Platforms (1) |
| GPL31089 |
[CCIA/UNSW] mouse PCR array version 1 |
|
| Samples (4)
|
|
| Relations |
| BioProject |
PRJNA788521 |
Less...
More...