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| Status |
Public on Nov 06, 2021 |
| Title |
CTI-2 inhibits metastasis and epithelial-mesenchymal transition of breast cancer cells by modulating MAPK signaling pathway |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Although some breast cancer patients die due to tumor metastasis rather than from the primary tumor, the molecular mechanism of metastasis remains unclear. Therefore, it is necessary to inhibit breast cancer metastasis during cancer treatment. In this case, after designing and synthesizing CTI-2, we found that CTI-2 treatment significantly reduced breast cancer cell metastasis in vivo and in vitro. Notably, with the treatment of CTI-2 in breast cancer cells, the expression level of E-cadherin increased, while the expression level of N-cadherin and vimentin decreased. In addition, after CTI-2 treatment, those outflow levels for p-ERK, p-p38, and p-JNK diminished, while no significant changes in the expression levels of ERK, JNK, or p38 were observed. Our conclusion suggested that CTI-2 inhibits the epithelial-mesenchymal transition (EMT) of breast carcinoma cells by inhibiting the activation of the mitogen-activated protein kinase (MAPK) signaling pathway, thereby inhibiting the metastasis of breast tumor cells. Therefore, we believe that CTI-2 is another candidate for breast tumor medication.
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| Overall design |
The mRNA profile of MDA-MB-231 cells treated with or without CTI-2 for 24 hours
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| Contributor(s) |
Ke J |
| Citation missing |
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| Submission date |
Nov 04, 2021 |
| Last update date |
Nov 06, 2021 |
| Contact name |
hui li |
| Organization name |
jilin university
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| Street address |
qianjinstreet
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| City |
Changchun |
| ZIP/Postal code |
130118 |
| Country |
China |
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| Platforms (1) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA777825 |
| SRA |
SRP344552 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE188144_All_gene_counts.list.txt.gz |
290.1 Kb |
(ftp)(http) |
TXT |
| GSE188144_All_gene_expression.list.txt.gz |
507.6 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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