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| Status |
Public on Feb 16, 2022 |
| Title |
mRAN expression profiles in bone marrow mesenchymal stem cells (MSC) from Wild Type and Lama4-deficient mice co-cultured with MLL-AF9 AML cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Bone marrow (BM) niche contributes to hematopoietic regeneration and can be remodeled by leukemic cells. We have found that Lama4 deletion in mouse mesenchymal stem cells (MSCs) could promote the proliferation of MLL-AF9 acute myeloid leukemia (AML) cells and chemoresistance of the cells to chemotherapy cytarabine. However, whether Lama4 deficient MSCs are more susseptible for AML cell remodeling remains to be explored. Here we report that differential molecular alterations in Lama4 deficient MSCs compared to wild type MSCs after being exposed to the AML cells for 48hours, which might be related to the enhanced AML cell proliferation and chemoresistance.
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| Overall design |
Examination of mRNA profiles in mesenchymal stem cells (CD45-TER119-CD31-CD44-CD51+SCA1+) from Wild Type and Lama4-deficient mice co-cultured with MLL-AF9 AML cells
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| Contributor(s) |
Qian H, Kondo M, Cai H, Sandhow L, Xiao P, Johansson A, Sasaki T, Tryggvarson K, Ekblom M |
| Citation(s) |
34958665 |
| |
| Submission date |
Oct 13, 2021 |
| Last update date |
Feb 16, 2022 |
| Contact name |
Hong Qian |
| E-mail(s) |
[email protected]
|
| Organization name |
Karolinska Institute
|
| Department |
Department of Medicine
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| Lab |
Hong Qian Group
|
| Street address |
Hälsovägen 7C (lastkaj), 14157 Huddinge/Stockholm
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| City |
Stockholm |
| ZIP/Postal code |
171 77 |
| Country |
Sweden |
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| Platforms (1) |
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| Samples (22)
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| Relations |
| BioProject |
PRJNA770993 |
| SRA |
SRP341220 |
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