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| Status |
Public on Jun 05, 2021 |
| Title |
The study of the effects of dauricine(dau) on human pancreatic carcinoma cells [miRNA] |
| Platform organisms |
Homo sapiens; Mus musculus; Rattus norvegicus |
| Sample organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
Pancreatic cancer is one of the most malignant digestive tract tumors with the worst prognosis. Few treatments are available; thus, the discovery of potential new anti-cancer agents has always been a hot issue. Dauricine (Dau) can inhibit the proliferation of the pancreatic cancer cell line BxPC3, and has the potential to be used as an adjuvant drug against pancreatic cancer; however, how Dau inhibits tumor cell proliferation has not been elucidated. To unravel the effects of Dau on proteins and metabolic pathways of pancreatic cancer cells, and to elucidate its anticancer mechanisms, we evaluated mRNA and microRNA expression in BxPC3 cells treated with Dau.
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| Overall design |
The samples included 3 groups of untreated BxPC3 cells and 3 groups of BxPC3 cells treated with 24 μmol Dau for 72h. Extract total RNA,then sequece mRNA.
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| Contributor(s) |
Bai Y, Jiang L |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jun 04, 2021 |
| Last update date |
Jun 07, 2021 |
| Contact name |
Yun Bai |
| E-mail(s) |
[email protected]
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| Phone |
+8613304642998
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| Organization name |
Hei Long Jiang University of Chinese medicine
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| Street address |
No.24 heping Street, XiangFang district
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| City |
Harbin |
| State/province |
Hei Long Jiang |
| ZIP/Postal code |
150040 |
| Country |
China |
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| Platforms (1) |
| GPL17728 |
miRCURY LNA microRNA Array, 7th generation - hsa, mmu & rno (miRBase 19.0) |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE176164 |
The study of the effects of dauricine(dau) on human pancreatic carcinoma cells |
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| Relations |
| BioProject |
PRJNA735202 |
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