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| Status |
Public on Aug 10, 2009 |
| Title |
Particulate Matter effect on Mouse Model of Cardiac Failure: Lung and Heart Left Ventricle |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Particulate Matter Triggers Carotid Body Dysfunction, Respiratory Dysynchrony and Cardiac Arrhythmias in Mice with Cardiac Failure
The mechanistic link between human exposure to airborne particulate matter (PM) pollution and the increased cardiovascular morbidity and mortality observed in people with congestive heart failure (CHF) is unknown. We now show that exposure of genetically-engineered mice with CHF (expressing a cardiac-specific CREB mutant transcription factor) to ambient PM (collected in Baltimore, mean aerodynamic diameter 1.9 um) unmasks severe autonomic morbidities manifested as significant reductions in heart rate variability, respiratory dysynchrony and increased frequency of serious ventricular arrhythmias, features not observed in PM-challenged wild type mice without CHF. PM exposure in CREB mice with CHF reflexly triggers autonomic dysfunction via heightened carotid body function as evidenced by pronounced afferent nerve responses to hypoxia and marked depression of breathing by hyperoxia challenge. Genomic analyses of lung and ventricular tissues revealed PM-induced molecular signatures of inflammation and oxidative stress. These findings in a murine model of cardiac failure provide the first direct assessment of autonomic function in response to PM challenge and are highly consistent with current epidemiologic findings on cardiovascular morbidity in susceptible PM-exposed human populations.
We utilized a murine model of dilated cardiomyopathy to address potential mechanistic links between PM exposure and the development of life-threatening cardiac dysrhythmias.
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| Overall design |
four group (n=3) of animals were treated by PBS or particulate matter (20mg/kg 1.9µm particulate matter) in Wild type or CD-1 dominate negative mice
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| Contributor(s) |
Lang GD, Moreno-Vinasco L, Wang T, Huang Y, Goonewardena SN, Peng YJ, Svensson EC, Natarajan V, Lang RM, Beshai J, Breysse PN, Geyh AS, Samet JM, Lussier YS, Prabhakar NR, Garcia JG |
| Citation(s) |
22108299 |
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| Submission date |
Aug 03, 2009 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Yong Huang |
| E-mail(s) |
[email protected]
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| Phone |
(434) 243-0842
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| Organization name |
University of Viginia
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| Department |
Medicine
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| Street address |
1340 Jefferson Park Ave
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| City |
Charlottesville |
| State/province |
VA |
| ZIP/Postal code |
22908 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA118759 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE17478_RAW.tar |
95.4 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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