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| Status |
Public on Feb 07, 2023 |
| Title |
THADA deficiency improves glycemic control by promoting pancreatic β-cell function and survival under physiological and diabetic conditions |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Purpose: The goals of this study are to explore the role of THADA in glucose homeostasis and insulin secretion
Methods: Thada-activated beta-cell line was generated by CRISPR/dCas9-SAM system. Cells infected with dCas9 and non-targeting sgRNA lentiviruses were used as controls.
Results: Transcriptomics analyses revealed that many genes were dys-regulated in beta-cells after THADA activation.
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| |
|
| Overall design |
mRNA profiles of control min6 cells (CON) and Thada-activated min6 cells (SAM)
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| |
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| Contributor(s) |
Zhang Y, Han S |
| Citation(s) |
36823211 |
| |
| Submission date |
Apr 25, 2021 |
| Last update date |
Mar 15, 2023 |
| Contact name |
Shan Han |
| E-mail(s) |
[email protected]
|
| Phone |
+8615632370207
|
| Organization name |
Shandong University
|
| Street address |
Wenhua West road
|
| City |
Jinan |
| ZIP/Postal code |
050000 |
| Country |
China |
| |
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| Platforms (1) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA724995 |
| SRA |
SRP316246 |
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