|
| Status |
Public on Apr 19, 2022 |
| Title |
m6A mRNA modification is a rheostat to maintain colonic epithelial cell homeostasis [scRNA-seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The function of m6A modification in colonic epithelial cells has been validated in our study that depletion of METTL14 in colonic epithelial cells triggers cell death. To further explore the biological effects of m6A deficiency in colonic epithelial cell heterogeneity, we performed single cell RNA-seq of colonic epithelial cells form 2-week-old Mettl14-KO and WT control mice
|
| |
|
| Overall design |
Single Cell Profiles of Mettl14 WT and Mettl14 KO colonic epithelial cells of two weeks
|
| |
|
| Contributor(s) |
Zhang T, Li H |
| Citation(s) |
35333576 |
| |
| Submission date |
Apr 03, 2021 |
| Last update date |
Apr 19, 2022 |
| Contact name |
Bing Hua Li |
| E-mail(s) |
[email protected]
|
| Organization name |
Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine
|
| Street address |
280 Chongqing South Rd, Building #5, Room 602, Shanghai
|
| City |
Shanghai |
| ZIP/Postal code |
200021 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (2) |
|
| This SubSeries is part of SuperSeries: |
| GSE171423 |
m6A mRNA modification is a rheostat to maintain colonic epithelial cell homeostasis |
|
| Relations |
| BioProject |
PRJNA719513 |
| SRA |
SRP313336 |
