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| Status |
Public on Sep 21, 2021 |
| Title |
NSD2 amplifies oncogenic transcriptional output to promote lung adenocarcinoma pathogenesis [CUT&RUN] |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
RNA-seq of kras and kras;NSD2 driven tumor biopsies and RNA-seq and Cut-and-run of kras;NSD2 derived cells suggests NSD2 amplifies Ras-output at chromatin and separately activates oncogenic-promoting gene expression programs.
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| Overall design |
RNA-seq was performed using tumor biopsies from kras and kras;NSD2 mice and compared to wild type lungs. In a separate study, RNA-seq and cut and run was performed in cell lines derived from the tumor biopsies of kras;NSD2 mice (KN cells±sgNSD2).
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| Contributor(s) |
Sengupta D, Zeng L, Li Y, Hausmann S, Ghosh D, Yuan G, Nguyen TN, Caporicci M, Yang X, Coles GL, Kharchenko V, Czaban I, Azhibek D, Fischle W, Jaremko M, Wistuba II, Sage J, Jaremko Å, Li W, Mazur PK, Gozani O |
| Citation(s) |
34555356 |
| |
| Submission date |
Mar 31, 2021 |
| Last update date |
Dec 21, 2021 |
| Contact name |
Yumei Li |
| E-mail(s) |
[email protected]
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| Organization name |
University of California, Irvine
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| Department |
Department of Biological Chemistry
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| Street address |
825 Health Sciences Road
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| City |
Irvine |
| State/province |
CA |
| ZIP/Postal code |
92697 |
| Country |
USA |
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| Platforms (1) |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE171218 |
NSD2 amplifies oncogenic transcriptional output to promote lung adenocarcinoma pathogenesis |
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| Relations |
| BioProject |
PRJNA718812 |
| SRA |
SRP312883 |
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