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| Status |
Public on Mar 25, 2021 |
| Title |
RNA-Seq of genetically engineered mouse model of Epithelioid Hemangioendothelioma tumors |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Epithelioid hemangioendothelioma (EHE) is a rare vascular sarcoma that is associated with a WWTR1-CAMTA1 fusion gene in greater than 90% of cases. Using an adaptation of the FLEx system, we generated a genetically engineered mouse model of EHE whereby the endogenous Wwtr1 Locus is replaced with an Wwtr1-Camta1 locus. RNA was isolated from the resultant tumors and from control liver tissue and RNA sequencing was performed. Cross species analysis between human and mice tumors demonstrated murine EHE maintains the defining transcriptional features of human EHE.
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| |
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| Overall design |
RNA Sequencing of Epithelioid Hemangioendothelioma Tumors in Human
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| |
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| Contributor(s) |
Rubin BP, Seavey CN |
| Citation(s) |
33766982 |
| |
| Submission date |
Mar 08, 2021 |
| Last update date |
Apr 26, 2021 |
| Contact name |
Brian P Rubin |
| Organization name |
Cleveland Clinic
|
| Department |
Cancer Biology
|
| Street address |
9620 Carnegie Ave NE2-215
|
| City |
Cleveland |
| State/province |
OH |
| ZIP/Postal code |
44106 |
| Country |
USA |
| |
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| Platforms (1) |
|
| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE168495 |
RNA-seq of Human Epithelioid Hemangioendothelioma and genetically engineered mouse model of EHE |
|
| Relations |
| BioProject |
PRJNA707561 |
| SRA |
SRP309822 |
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