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| Status |
Public on Jun 01, 2010 |
| Title |
Gene expression data from S. aureus-exposed neutrophils |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Neutrophil lysis after phagocytosis is a process potentially important in the pathogenesis of community-associated methicillin-resistant S. aureus (CA-MRSA) infection. The mechanism for this process is not currently known. Therefore, to better understand CA-MRSA virulence we used human oligonucleotide microarrays to investigate the mechanism underlying enhanced PMN lysis that occurs after phagocytosis of CA-MRSA.
In order to examine the effect of S. aureus on the neutrophil transcriptome and to elucidate any possible differences in this effect between hospital- and community-associated S. aureus, we performed microarray expression analysis on human neutrophils treated with hospital- and community-associated S. aureus.
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| Overall design |
Polymorphonuclear leukocytes (PMNs) were isolated from the blood of healthy donors. Control and S. aureus-exposed PMNs were incubated at 37C for 1, 2, 3 or 6 hours.
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| Contributor(s) |
Palazzolo-Ballance AM, Kobayashi SD, Kennedy AD, Braughton KR, Whitney AR, Sturdevant DE, Dorward DW, Kreiswirth BN, Musser JM, DeLeo FR |
| Citation(s) |
20587998 |
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| Submission date |
Jun 25, 2009 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Addie Whitney |
| E-mail(s) |
[email protected]
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| Organization name |
NIH/NIAID/RML
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| Department |
LHBP
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| Lab |
DeLeo
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| Street address |
903 S 4th St
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| City |
Hamilton |
| State/province |
MT |
| ZIP/Postal code |
59840 |
| Country |
USA |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (113)
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| Relations |
| BioProject |
PRJNA117601 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE16837_RAW.tar |
557.4 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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