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| Status |
Public on Jan 17, 2021 |
| Title |
Transcriptome analysis of potential candidate genes and molecular pathways in colitis-associated colorectal cancer of Mkp-1-deficient mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The nuclear phosphatase mitogen-activate protein kinase phosphatase-1 (MKP-1) is a key negative regulator of the innate immune response through the regulation of the biosynthesis of proinflammatory cytokines. In colorectal cancer (CRC), which is induced mainly by chronic inflammation, Mkp-1 overexpression was found in addition to disturbances in Mkp-1 functions, which may play a role in cancer development in different types of tumors. However, the potential molecular mechanisms by which Mkp-1 influences CRC development is not clear. Here, we performed global gene expression profiling of Mkp-1 KO mice using RNA sequencing (RNA-seq) to explore the role of Mkp-1 in CRC progression using transcriptome analysis.
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| Overall design |
Two main categories including wild type that subdivided to three subgroups; wild type control (WT-C), wild type adenoma stage (WT-AS), wild type carcinoma stage (WT-CS), and Mkp-1 KO type that subdivided to three subgroups; Mkp-1 KO control (Mkp-1 KO C), Mkp-1 KO adenoma stage (Mkp-1 KO AS), Mkp-1 KO carcinoma stage (Mkp-1 KO CS).
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| |
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| Contributor(s) |
Tang X, Hammad A |
| Citation(s) |
34034704 |
| |
| Submission date |
Jan 16, 2021 |
| Last update date |
May 31, 2021 |
| Contact name |
XIUWEN TANG |
| E-mail(s) |
[email protected]
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| Organization name |
ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE
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| Department |
BIOCHEMISTRY AND GENETICS
|
| Street address |
YUHANGTONG ROAD
|
| City |
HANGZHOU |
| ZIP/Postal code |
310000 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA692624 |
| SRA |
SRP302053 |
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