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Series GSE157126 Query DataSets for GSE157126
Status Public on May 16, 2022
Title Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Breast cancer is a leading cause of death in premenopausal women. Progesterone drives expansion of luminal progenitor cells, leading to the development of poor-prognostic breast cancers. However, it is not known if antagonising progesterone can prevent breast cancers in humans. We suggest that targeting progesterone signalling could be a means of reducing features which are known to promote breast cancer formation.
 
Overall design Core needle breast biopsies collected at baseline and after two months of 50 mg mifepristone treatment every other day from healthy women (n=16), aged 18-35 years, with regular menstrual cycles and with no hormonal treatment. BRCA1/2 mutation status was not assessed for these subjects.
Web link https://pubmed.ncbi.nlm.nih.gov/35701800/
 
Contributor(s) Bogavarappu NR
Citation(s) 35701800
Submission date Aug 29, 2020
Last update date Dec 20, 2023
Contact name Nageswara Rao Boggavarapu
E-mail(s) [email protected]
Organization name Karolinska Institutet
Department Women and Children health
Lab Bioclinicum J9:30
Street address Visionsgatan 4
City Solna
State/province stockholm
ZIP/Postal code 17164
Country Sweden
 
Platforms (1)
GPL21697 NextSeq 550 (Homo sapiens)
Samples (32)
GSM4753530 Subject 1 before Mifepristone treatment
GSM4753531 Subject 1 After Mifepristone treatment
GSM4753532 Subject 2 before Mifepristone treatment
Relations
BioProject PRJNA660182
SRA SRP279323

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE157126_Counts_Filtered.txt.gz 2.5 Mb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record
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