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| Status |
Public on Dec 31, 2020 |
| Title |
Receptor Notch-3 - role in kidney fibrosis using an UUO model |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Gene array of kidney tissue of wild type and Notch-3 knockout mice was performed following unilateral ureteral obstruction (UUO).
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| Overall design |
Kidney fibrosis and inflammation were analyzed following unilateral ureteral obstruction (UUO). UUO was performed with gender matched 12-16 weeks old mice. The right ureters of wild type and Notch3 knockout mice were ligated for 5 days. Both kidneys were collected for preparation of cortical RNA. Contralateral (left untretaed kidney) were harvested for comparative analyses. To gain insight into the mechanism(s) by which Notch3-deficiency alters the pattern of kidney damage, gene expression analysis of UUO kidneys is performed. The expression of fibrosis relevant genes, cytokines&chemokines as well as Notch receptor family members was compared in wild type UUO day 5 samples versus Notch3-/- UUO day 5 samples.
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| Contributor(s) |
Brandt S, Geffers R, Mertens PR |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Aug 13, 2020 |
| Last update date |
Jan 02, 2021 |
| Contact name |
Robert Geffers |
| E-mail(s) |
[email protected]
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| Phone |
+49 531-6181-3058
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| Organization name |
HCI - Helmholtz Centre for Infection Research
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| Department |
Dep. Molecular Bacteriology
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| Lab |
Genome Analytics
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| Street address |
Inhoffenstr. 7
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| City |
Braunschweig |
| ZIP/Postal code |
38124 |
| Country |
Germany |
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| Platforms (1) |
| GPL11202 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA657003 |
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