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| Status |
Public on Apr 21, 2010 |
| Title |
Involvement of the Chromatin Modifier ATX1 and of the Arabidopsis Myotubularin Homolog (MYO1) in the Response to Drought |
| Organism |
Arabidopsis thaliana |
| Experiment type |
Expression profiling by array
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| Summary |
Plants respond to environmental stresses by altering transcription of genes involved in the response. The chromatin modifier ATX1 influences gene expression and factors that modulate ATX1 activity would affect indirectly the expression of ATX1-regulated genes. Here, we demonstrate that dehydration is such a factor indicating that ATX1 is involved in the plant’s response to drought. In addition, we show that a hitherto unknown Arabidopsis gene, At3g10550, encodes MYO1, a phosphoinositide 3’-phosphatase related to the animal myotubularins. By a functional genomics approach, we show that ATX1 and MYO1 participate in overlapping drought-response pathways. The shared set of genes, representing the ultimate targets of an ATX1-MYO1 signaling mechanism responding to drought, provided insights into the relationship of the epigenetic factor and the lipid phosphatase from the other end of the response pathway.
Keywords: control/treatment
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| Overall design |
Arabidopsis thaliana Col0 wild type, atx1 mutant, and MYO-OX line RNA was isolated from control (watered) and treatment (water-deficit) samples for analysis on microarrays with two biological reps.
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| Contributor(s) |
Ding Y, Lapko H, Ndamukong I, Xia Y, Al-Abdallat A, Lalithambika S, Sadder M, Saleh A, Fromm ME, Riethoven JM, Lu G, Avramova Z |
| Citation(s) |
19901554, 22324391 |
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| Submission date |
Apr 06, 2009 |
| Last update date |
Aug 15, 2018 |
| Contact name |
Jean-Jack M. Riethoven |
| E-mail(s) |
[email protected]
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| Organization name |
University of Nebraska-Lincoln
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| Department |
Beadle Center for Biotechnology
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| Lab |
Bioinformatics Core Research Facility
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| Street address |
1901 Vine Street
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| City |
Lincoln |
| State/province |
NE |
| ZIP/Postal code |
68588-0665 |
| Country |
USA |
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| Platforms (1) |
| GPL198 |
[ATH1-121501] Affymetrix Arabidopsis ATH1 Genome Array |
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| Samples (12)
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| Relations |
| Affiliated with |
GSE69995 |
| BioProject |
PRJNA115757 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE15577_RAW.tar |
25.5 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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