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Series GSE154733 Query DataSets for GSE154733
Status Public on Nov 16, 2020
Title Gene expression signatures of CD11b+ cells in mice after myocardial infarction
Organism Mus musculus
Experiment type Expression profiling by array
Summary To further search for potential gene targets which are involved in the pathological process of myocardial infarction, we have employed whole genome microarray expression profiling as a discovery platform to identify the expression of STAT6, β1-adrenergic receptors and inflammatory cytokines. The CD11b+ cells were isolated from spleen and bone marrow of mice by magnetic beads, and the experimental mice were divided into four time points (control, MI 1week, MI 2 weeks, and MI 4 weeks). We found the β1-AR related sympathetic signal, the STAT6 signal and inflammatory cytokines (IL-1α, IL-18 and TGF-β) are involved in the activation of CD11b+ immune cells and cardiac fibrogenesis after myocardial infarction.
 
Overall design The gene expression was measured in spleen-derived and bone marrow-derived CD11b+ cells of mice. Mice were divided into four groups (control, MI 1week, MI 2 weeks and MI 4 weeks). There were five mice in each group.
 
Contributor(s) Yang X, Zhang W
Citation https://doi.org/10.3389/fphys.2020.579712
Submission date Jul 20, 2020
Last update date Nov 16, 2020
Contact name Xiangdong Yang
E-mail(s) [email protected]
Organization name Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University
Street address 180 Fenglin Road, Xuhui District, Shanghai
City Shanghai
State/province China
ZIP/Postal code 200032
Country China
 
Platforms (1)
GPL11202 Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version)
Samples (24)
GSM4677996 WT_ spleen-derived CD11b+ cells _control
GSM4677997 WT_ spleen-derived CD11b+ cells _MI
GSM4677998 WT_ spleen-derived CD11b+ cells _MI 2 weeks
Relations
BioProject PRJNA647355

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE154733_Processed_normalized_data.xlsx 37.3 Mb (ftp)(http) XLSX
GSE154733_RAW.tar 47.5 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table
Processed data are available on Series record
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