|
| Status |
Public on Apr 05, 2022 |
| Title |
Expression profiling in liver of wild type and Ppara-null mice treated with PPARA agonists [RNA-seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To clarify the mechanism underlying the proliferation of hepatocytes induced by PPARA agonists, expression profiling in liver of wild type and Ppara-null mice treated with PPARA agonist was investigated.
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| |
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| Overall design |
RNA was extracted from the liver of wild type (Ppara+/+), and Ppara-null (Ppara-/-) mice treated with the PPARA agonist (Wy14,643 or Fenofibrte). RNA purified were then used to generate libraries and sequenced.
|
| Web link |
https://www.sciencedirect.com/science/article/pii/S2589004222004667?via%3Dihub
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| |
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| Contributor(s) |
Brocker CN, Yagai T, Aibara D, Takahashi S, Gonzalez FJ |
| Citation(s) |
35479397 |
| |
| Submission date |
Jul 12, 2020 |
| Last update date |
May 05, 2022 |
| Contact name |
Frank J. Gonzalez |
| E-mail(s) |
[email protected]
|
| Organization name |
National Institutes of Health
|
| Department |
National Cancer Institute
|
| Lab |
Laboratory of Metabolism
|
| Street address |
37 Convent Drive. Bldg37/Rm3106
|
| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20892 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
|
| Samples (18)
|
| GSM4668284 |
Wy14,643-Ppara+/+1 (4 mouse liver mix) |
| GSM4668285 |
Wy14,643-Ppara+/+2 (4 mouse liver mix) |
| GSM4668286 |
Wy14,643-Ppara+/+3 (5 mouse liver mix) |
| GSM4668287 |
Fenofibrate-Ppara+/+1 (3 mouse liver mix) |
| GSM4668288 |
Fenofibrate-Ppara+/+2 (3 mouse liver mix) |
| GSM4668289 |
Fenofibrate-Ppara+/+3 (3 mouse liver mix) |
| GSM4668299 |
Control-Ppara-/-1 (4 mouse liver mix) |
| GSM4668300 |
Control-Ppara-/-2 (4 mouse liver mix) |
| GSM4668301 |
Control-Ppara-/-3 (5 mouse liver mix) |
| GSM4668302 |
Wy14,643-Ppara-/-1 (3 mouse liver mix) |
| GSM4668303 |
Wy14,643-Ppara-/-2 (3 mouse liver mix) |
| GSM4668304 |
Wy14,643-Ppara-/-3 (4 mouse liver mix) |
| GSM4668305 |
Fenofibrate-Ppara-/-1 (3 mouse liver mix) |
| GSM4668306 |
Fenofibrate-Ppara-/-2 (3 mouse liver mix) |
| GSM4668307 |
Fenofibrate-Ppara-/-3 (4 mouse liver mix) |
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| This SubSeries is part of SuperSeries: |
| GSE154277 |
Gene repression through epigenetic modulation by PPARA enhances hepatocellular proliferation |
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| Relations |
| BioProject |
PRJNA645712 |
| SRA |
SRP271485 |
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