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| Status |
Public on Jul 10, 2020 |
| Title |
Expression data from gastric cancer organoids |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
To understand the molecular basis of the acquisition of 5-FU resistance in gastric cancer stem cells, we established 5-FU-resistant gastric cancer organoids.
We used microarrays to detail the global program of gene expression underlying 5-FU resistance and maintenance of stem cell properties in gastric cancer.
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| Overall design |
To scrutinise the mechanism involved in the acquisition of 5-FU resistance in GC stem cells, we established 3 GCOs from surgically resected specimens. We then tried to establish GCOs with acquired resistance to 5-FU by continuous and stepwise escalation of 5-FU in the culture media. Normal gastric organoid are employed as controls.
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| Contributor(s) |
Ukai S, Sakamoto N |
| Citation(s) |
33046798 |
| |
| Submission date |
Jul 09, 2020 |
| Last update date |
Apr 18, 2023 |
| Contact name |
Shoichi Ukai |
| Organization name |
Hiroshima University
|
| Street address |
minami-ku kasumi 1-2-3
|
| City |
hiroshima |
| ZIP/Postal code |
7348551 |
| Country |
Japan |
| |
|
| Platforms (1) |
| GPL23126 |
[Clariom_D_Human] Affymetrix Human Clariom D Assay [transcript (gene) version] |
|
| Samples (10)
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| GSM4664311 |
Normal gastric organoid biological rep 1 |
| GSM4664312 |
Normal gastric organoid biological rep 2 |
| GSM4664313 |
Normal gastric organoid biological rep 3 |
| GSM4664314 |
Normal gastric organoid biological rep 4 |
| GSM4664315 |
Parental gastric cancer organoid biological rep 1 |
| GSM4664316 |
Parental gastric cancer organoid biological rep 2 |
| GSM4664317 |
Parental gastric cancer organoid biological rep 3 |
| GSM4664318 |
5-FU resistant gastric cancer organoid biological rep 1 |
| GSM4664319 |
5-FU resistant gastric cancer organoid biological rep 2 |
| GSM4664320 |
5-FU resistant gastric cancer organoid biological rep 3 |
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| Relations |
| BioProject |
PRJNA645258 |
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