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| Status |
Public on Apr 30, 2020 |
| Title |
ND1 ex vivo gene therapy modulates the transcription of genes relevant to AD pathogenesis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Transcriptome analysis of human iPSC-derived hippocampal neurons overexpresing NEUROD1
We employed Affymetrix GeneChip microarray (Human Clariom D) to examine early transcriptomic changes in APP variant cells compared to control, upon viral delivery of ND1.
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| Overall design |
Human iPSC-derived hippocampal neurons from healthy donor and Alzheimer's disease patient carrying APP mutation were transfected with GFP or NEUROD1. Three biological replicates were performed. Summarized probe set signals in log2 scale were calculated by using the GCCN-SST-RMA algorithm with the Affymetrix GeneChip Expression Console v1.4 Software.
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| Contributor(s) |
Pomeshchi Y, Klementieva O, Gil J, Martinsson I, Hansen MG, de Vries T, Sancho-Balsells A, Russ K, Savchenko E, Collin A, Vaz AR, Bagnoli S, Nacmias B, Rampon C, Sorbi S, Brites D, Marko-Varga G, Kokaia Z, Rezeli M, Gouras GK, Roybon L |
| Citation(s) |
32589876 |
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| Submission date |
Apr 29, 2020 |
| Last update date |
Jul 30, 2020 |
| Contact name |
Jeovanis Gil Valdés |
| E-mail(s) |
[email protected]
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| Phone |
+46728789411
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| Organization name |
Lund University
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| Department |
Department of Biomedical Engineering
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| Lab |
Clinical Protein Science and Imaging
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| Street address |
Sölvegatan 19, BMC D13
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| City |
Lund |
| State/province |
Skane |
| ZIP/Postal code |
221 84 |
| Country |
Sweden |
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| Platforms (1) |
| GPL23126 |
[Clariom_D_Human] Affymetrix Human Clariom D Assay [transcript (gene) version] |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA629335 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE149599_P236_Affymetrix_Result_SST-RMA_GENE_LEVEL.xlsx |
143.7 Mb |
(ftp)(http) |
XLSX |
| GSE149599_RAW.tar |
323.3 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
| Processed data are available on Series record |
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