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| Status |
Public on Jun 22, 2022 |
| Title |
A Drosophila proto-oncogene homolog controls aggression via aminergic neurons |
| Organism |
Drosophila melanogaster |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Modulation of action choices according to the environmental context is crucial for animal survival and reproductive success1. Aggression, despite its general importance as a social behavior2, can become detrimental if uncontrolled3,4. However, the genetic and neural basis for aggression control through active suppression remains largely unknown. Here we found nvy, a Drosophila homolog of vertebrate myeloid translocation gene (MTG)5 involved in transcriptional regulation6-8, suppresses aggression through a specific subset of neurons. Mutation of the nvy gene resulted in hyper-aggressiveness, which was rescued by neuronal expression of human MTGs as well as Drosophila nvy. The mutant exhibited persistent aggression under various contexts in which wild-type flies switch their behavioral patterns. Knockdown of nvy in octopaminergic/tyraminergic (OA/TA) neurons increased aggression, phenocopying the nvy deletion. Cell-type specific transcriptomics on OA/TA neurons derived from the nvy mutants revealed aggression-controlling genes that are likely downstream of nvy. Moreover, we found that the nvy-expressing OA/TA neuronal subpopulations specifically suppress aggression. Our results presents a powerful genetic model to unravel not only the neuronal systems that modulate aggression in a social context-dependent manner, but also the conserved molecular mechanism underlying the tumorigenesis caused by the MTG mutations.
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| Overall design |
Transcriptional profiles of octopaminergic/tyraminergic neurons of wild-type and nervy-mutant fruit flies using single-cell RNA-sequencing technology.
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| Contributor(s) |
Ishii K, Cortese M, Leng X, Wohl M, Shokhirev MN, Pinto AM, Asahina K |
| Citation(s) |
36070378 |
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| Submission date |
Apr 14, 2020 |
| Last update date |
Oct 21, 2022 |
| Contact name |
April Elizabeth Williams |
| E-mail(s) |
[email protected], [email protected]
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| Phone |
7345461645
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| Organization name |
Salk Institute for Biological Studies
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| Department |
IGC
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| Street address |
10010 N Torrey Pines Rd
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| City |
San Diego |
| State/province |
California |
| ZIP/Postal code |
92037 |
| Country |
USA |
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| Platforms (1) |
| GPL19132 |
Illumina NextSeq 500 (Drosophila melanogaster) |
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| Samples (212)
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| Relations |
| BioProject |
PRJNA625242 |
| SRA |
SRP256327 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE148630_raw.txt.gz |
3.0 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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