|
| Status |
Public on Jul 02, 2020 |
| Title |
Combined Inhibition of JAK/STAT Pathway and Lysine Demethylase 1 as a Novel Therapeutic Strategy in CSF3R/CEBPA Mutant Acute Myeloid Leukemia [LSD1i RNA-seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The presence of CSF3R mutations are associated with adverse outcomes in CEBPA mutant AML. Here we report that inhibitors of LSD1 reverse the mutant CEBPA-mediated differentiation blockade and exhibit synergy with JAK/STAT inhibitors.
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| |
|
| Overall design |
Comparison of gene expression in mouse bone marrow cells retrovirally expressing mutant CSF3R and CEBPA and treated with GSK-LSD1 or DMSO for 48 hours.
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| |
|
| Contributor(s) |
Braun TP, Maxson JE |
| Citation(s) |
32471953 |
| |
| Submission date |
Oct 03, 2019 |
| Last update date |
Jul 02, 2020 |
| Contact name |
Theodore Paul Braun |
| E-mail(s) |
[email protected]
|
| Organization name |
OHSU
|
| Department |
Knight Cancer Institute
|
| Lab |
3181 SW Sam Jackson Park Road
|
| Street address |
3181 SW Sam Jackson Park Road
|
| City |
Portland |
| State/province |
OR |
| ZIP/Postal code |
97239 |
| Country |
USA |
| |
|
| Platforms (1) |
|
| Samples (6)
|
| GSM4106420 |
RNA-seq on DMSO treated murine leukemia cells 1 |
| GSM4106421 |
RNA-seq on DMSO treated murine leukemia cells 2 |
| GSM4106422 |
RNA-seq on DMSO treated murine leukemia cells 3 |
| GSM4106423 |
RNA-seq on GSKLSD1 treated murine leukemia cells 1 |
| GSM4106424 |
RNA-seq on GSKLSD1 treated murine leukemia cells 2 |
| GSM4106425 |
RNA-seq on GSKLSD1 treated murine leukemia cells 3 |
|
| This SubSeries is part of SuperSeries: |
| GSE138388 |
Combined Inhibition of JAK/STAT Pathway and Lysine Demethylase 1 as a Novel Therapeutic Strategy in CSF3R/CEBPA Mutant Acute Myeloid Leukemia |
|
| Relations |
| BioProject |
PRJNA575724 |
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