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| Status |
Public on Aug 05, 2020 |
| Title |
Effects of entero-gastro-anastomosis (EGA) surgery in ob/ob mice on pancreatic islet gene expression |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Bariatric surgical techniques are known to cause weight loss and diabetes remission to varying degrees in severly obese patients. However, the mechanisms involved in the restoration of beta-cell function remain to be uncovered. In this study, the leptin-deficient ob/ob mouse was used as a model to investigate the effect of EGA bariactric surgery on pancreatic islet gene expression.
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| Overall design |
At 3 months of age, C57Bl6-ob/ob mice were randomized to EGA or sham surgery. Pancreatic islets were isolated 28 days after the surgery. C57Bl/6J mouse islets were used as lean/non-obese control.
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| Contributor(s) |
Amouyal C, Guay C, Regazzi R, Magnan C, Andreelli F |
| Citation(s) |
32739864 |
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| Submission date |
Jul 01, 2019 |
| Last update date |
Aug 05, 2020 |
| Contact name |
Claudiane Guay |
| E-mail(s) |
[email protected]
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| Phone |
+41216925281
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| Organization name |
University of Lausanne
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| Department |
DNF
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| Street address |
Du Bugnon 9
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| City |
Lausanne |
| State/province |
Vaud |
| ZIP/Postal code |
1005 |
| Country |
Switzerland |
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| Platforms (1) |
| GPL11202 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version) |
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| Samples (12)
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| This SubSeries is part of SuperSeries: |
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| Relations |
| BioProject |
PRJNA552806 |
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