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| Status |
Public on Apr 30, 2024 |
| Title |
Investigation of ST8SIA1 expression in icaritin-treated and untreated melanoma cell lines |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We identified that upregulation of ST8SIA1 promotes melanoma brain metastasis.
The goal of this RNA-seq is to analyze the ST8SIA1 expression in icaritin-treated and untreated melanoma cell lines (DP-0574 and WP-0614 cell lines)
In vitro functional studies demonstrate that ST8SIA1 overexpression promotes cell proliferation and colony formation and that this can be halted by icaritin treatment.
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| Overall design |
mRNA profiles of icaritin-treated or control untreated cells were generated by deep sequencing using Illumina NextSeq 550, in triplicate.
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| Contributor(s) |
Hoon DS, Ramos RI |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
May 09, 2019 |
| Last update date |
Apr 30, 2024 |
| Contact name |
Dave S.B. Hoon |
| E-mail(s) |
[email protected]
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| Organization name |
Saint John's Cancer Institute
|
| Department |
Translational Molecular Medicine
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| Street address |
2200 Santa Monica Boulevard
|
| City |
Santa Monica |
| State/province |
CA |
| ZIP/Postal code |
90403 |
| Country |
USA |
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| Platforms (1) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA542096 |
| SRA |
SRP197302 |
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