|
| Status |
Public on May 21, 2019 |
| Title |
Epigenetic activation and memory at a TGFB2 enhancer in systemic sclerosis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Epigenetic activation of an enhancer for TGFB2 locks SSc patient fibroblasts into a pro-fibrotic synthetic state through mechanisms dependent on NF-kB and BRD4.
|
| |
|
| Overall design |
Examination of chromatin accessibility and transcriptome of healthy control and patient fibroblasts
|
| |
|
| Contributor(s) |
Shin JY, Dietz HC |
| Citation(s) |
31217334 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| R01 AR068379 |
Mechanistic and Therapeutic Investigations of Scleroderma |
JOHNS HOPKINS UNIVERSITY |
Harry C., III Dietz |
|
| |
| Submission date |
Apr 25, 2019 |
| Last update date |
Oct 02, 2023 |
| Contact name |
Joseph Y Shin |
| E-mail(s) |
[email protected]
|
| Organization name |
Johns Hopkins University School of Medicine
|
| Street address |
733 N Broadway MRB-539
|
| City |
Baltimore |
| State/province |
MD |
| ZIP/Postal code |
21205 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
|
| Samples (24)
|
|
| Relations |
| BioProject |
PRJNA535485 |
| SRA |
SRP193855 |
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