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Series GSE128702 Query DataSets for GSE128702
Status Public on Mar 23, 2019
Title Molecular characterizaion of neuroendocrine-like bladder cancer
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Neuroendocrine bladder cancer is an aggressive variant of bladder cancer with significant metastatic potential and high risk of mortality. Diagnosis of these tumors is currently dependent on morphological criteria and staining for neuroendocrine markers. Using machine learning and multiple validation cohorts in different clinical settings, we developed a model that identifies tumors with transcriptomic profiles consistent with NE bladder cancers with an absence of NE features by morphological criteria. Early and accurate identification of these patients by genomic analysis may improve outcomes through treatment intensification and adaptation of standard treatment regimens.
 
Overall design In this study, we used transcriptome-wide expression profiles to generate a single-sample classifier to identify neuroendocrine-like muscle-invasive bladder tumors.  The classifier was validated on six independent cohorts, including a radical cystectomy cohort of 256 bladder cancer cases.
 
Contributor(s) da Costa JB, Gibb EA, Bivalacqua TJ, Liu Y, Oo HZ, Miyamoto DT, Alshalalfa M, Davicioni E, Wright J, Dall’Era MA, Douglas J, Boormans JL, Van der Heijden MS, Wu C, van Rhijn BW, Gupta S, Grivas P, Mouw KW, Murugan P, Fazli L, Ra S, Konety BR, Seiler R, Daneshmand S, Mian OY, Efstathiou JA, Lotan Y, Black PC
Citation(s) 31619281
Submission date Mar 21, 2019
Last update date Oct 29, 2019
Contact name Elai Davicioni
E-mail(s) [email protected]
Organization name GenomeDx
Street address 1152 Mainland St #430
City Vancouver
State/province BC
ZIP/Postal code V6B 4X2
Country Canada
 
Platforms (1)
GPL22995 [HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [transcript (gene) version, custom CDF]
Samples (256)
GSM3683043 bladder_cancer_resection_sample_1 [GNDX-VJM-VAL1]
GSM3683044 bladder_cancer_resection_sample_2 [GNDX-VJM-VAL2]
GSM3683045 bladder_cancer_resection_sample_3 [GNDX-VJM-VAL3]
Relations
BioProject PRJNA528581

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE128702_RAW.tar 5.3 Gb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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