|
| Status |
Public on Nov 04, 2008 |
| Title |
Expression profiling of normal murine lymphoid progenitors and MLL-AF4 leukemic lymphoblasts |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
We created a mouse model where conditional expression of physiologic levels of an Mll-AF4 fusion oncogene induces development of acute lymphoblastic (ALL) or acute myeloid leukemias (AML). Immunophenotypic and gene expression analysis of the ALL cells demonstrated bone marrow replacement with B-precursor cells which express a gene expression profile that has significant overlap with profiles in human MLL-rearranged ALL.
Keywords: Cell type comparison
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| |
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| Overall design |
Total RNA from normal pro-B, pre-B, immature B and mature B lymphocytes, and from leukemic pre-B cells was isolated and hybridized to Affymetrix expresison microarrays.
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| |
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| Contributor(s) |
Lemieux ME |
| Citation(s) |
18977325 |
| |
| Submission date |
Jul 31, 2008 |
| Last update date |
May 04, 2018 |
| Contact name |
Madeleine E. Lemieux |
| E-mail(s) |
[email protected]
|
| Phone |
617-595-6695
|
| URL |
http://www.bioinfo.ca
|
| Organization name |
Bioinfo
|
| Street address |
275 Main St., Suite 252
|
| City |
Plantagenet |
| State/province |
ON |
| ZIP/Postal code |
K0B 1L0 |
| Country |
Canada |
| |
|
| Platforms (1) |
| GPL8321 |
[Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array |
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| Samples (39)
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| This SubSeries is part of SuperSeries: |
| GSE12363 |
H3K79 methylation profiles define murine and human MLL-AF4 leukemias |
|
| Relations |
| BioProject |
PRJNA113843 |
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