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Series GSE121894 Query DataSets for GSE121894
Status Public on Apr 15, 2020
Title Gene expression profile of endothelial cells derived from circulating progenitors issued from patients with rheumatoid arthritis
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Synovial neoangiogenesis is an early and crucial event to promote the development of the hyperplasic proliferative pathologic synovium in rheumatoid arthritis (RA). Endothelial cells (ECs) are critical for the formation of new blood vessels since they highly contribute to angiogenesis and vasculogenesis.
To better characterize these cells, our group has studied the gene expression profiles of ECs issued from 18 RA patients compared to 11 healthy controls.
 
Overall design ECs derived from circulating endothelial progenitor cells (EPCs) were isolated from peripheral blood of RA patients and controls for RNA extraction and hybridization on Affymetrix microarrays. Gene expression profiles of EPC-derived ECs were determined in basal conditions and also after hypoxic exposure.
 
Contributor(s) Avouac J, Leblond A, Allanore Y
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Submission date Oct 29, 2018
Last update date Apr 17, 2020
Contact name Franck Letourneur
E-mail(s) [email protected]
Organization name INSERM
Department U1016
Lab genomic
Street address 22 rue mechain
City Paris
ZIP/Postal code 75014
Country France
 
Platforms (1)
GPL25734 [HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [CDF: Brainarray V 18, huex10st_Hs_ENTREZG_18.0.0]
Samples (58)
GSM3449621 RA EPC-derived endothelial cells - hypoxia - 1
GSM3449622 RA EPC-derived endothelial cells - basal - 1
GSM3449623 RA EPC-derived endothelial cells - hypoxia - 2
Relations
BioProject PRJNA499006

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE121894_RAW.tar 1.3 Gb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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