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| Status |
Public on Jul 31, 2018 |
| Title |
Integrative analysis of differentially expressed genes and miRNAs predicts complex T3-mediated protective circuits in a rat model of cardiac ischemia reperfusion |
| Organism |
Rattus norvegicus |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
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| Summary |
mRNA and miRNA expression profiling shows that the T3 supplementation reverted the expression of 87 genes and 11 miRNAs that were dysregulated in the untreated group
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| Overall design |
A rat model of myocardial IR, with or without an early short-term T3-replacement, was used to predict putative T3-dependent miRNA-gene interactions targeted to mitochondria quality control and wound healing repair. One Sham, two IR, and two IRT3 rats were collected for mirna profiling.
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| Contributor(s) |
D'Aurizio R, Forini F, Nicolini G, Kusmic C, Rizzo M, Baumgart M, Groth M, Doccini S, Iervasi G, Pitto L |
| Citation(s) |
30218079 |
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| Submission date |
Jun 20, 2018 |
| Last update date |
Nov 02, 2018 |
| Contact name |
Romina D'Aurizio |
| E-mail(s) |
[email protected]
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| Organization name |
CNR
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| Department |
IIT
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| Street address |
via Moruzzi 1
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| City |
Pisa |
| State/province |
PI |
| ZIP/Postal code |
56127 |
| Country |
Italy |
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| Platforms (1) |
| GPL18694 |
Illumina HiSeq 2500 (Rattus norvegicus) |
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| Samples (5)
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| Relations |
| BioProject |
PRJNA476918 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE116046_ExpressionCountsRPM.txt.gz |
8.6 Kb |
(ftp)(http) |
TXT |
| Raw data are available in SRA |
| Processed data are available on Series record |
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