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| Status |
Public on Jun 04, 2018 |
| Title |
Transcriptional profiling of HT-29 cells with different treatments |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Through RNA-seq, we investigated the transcriptional changes of necroptotic cell induced by TNF-α, SM-164 and zVAD. We report here that necroptosis leads to transcriptional activation of a large set of genes including pro-inflammatory cytokines, which is much stronger than that triggered by TNF-α alone. Furthermore, the robust induction of cytokine expression could be blocked by necroptotic inhibitor Nec-1s. Thus, we show that necroptosis exerts a profound effect on transcription, and activate the expression of pro-inflammatory genes, providing insights into the mechanism by which necroptosis promotes inflammation in human diseases.
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| Overall design |
Examination of the transcriptional changes of HT-29 cell with different treatments
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| Contributor(s) |
Yuan J, Qian L, Zhu K |
| Citation(s) |
29703889 |
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| Submission date |
Dec 29, 2017 |
| Last update date |
Dec 05, 2018 |
| Contact name |
Zaijun Ma |
| E-mail(s) |
[email protected]
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| Organization name |
Chinese Academy Science
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| Street address |
Qiuyue Road 26
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| City |
Shanghai |
| ZIP/Postal code |
200032 |
| Country |
China |
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| Platforms (1) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA427878 |
| SRA |
SRP127714 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE108621_DMSO_vs_TNF-alpha_DESeq.csv.gz |
968.1 Kb |
(ftp)(http) |
CSV |
| GSE108621_DMSO_vs_TSZ_DESeq.csv.gz |
1.1 Mb |
(ftp)(http) |
CSV |
| GSE108621_DMSO_vs_TSZ_Nec-1s_DESeq.csv.gz |
1017.6 Kb |
(ftp)(http) |
CSV |
| GSE108621_TNF-alpha_vs_TSZ_DESeq.csv.gz |
1.0 Mb |
(ftp)(http) |
CSV |
| GSE108621_TNF-alpha_vs_TSZ_Nec-1s_DESeq.csv.gz |
978.6 Kb |
(ftp)(http) |
CSV |
| GSE108621_TSZ_vs_TSZ_Nec-1s_DESeq.csv.gz |
1.0 Mb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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