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| Status |
Public on Apr 09, 2008 |
| Title |
Comparison of SCG expression profiles from Bax null versus NGF-Bax double null mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
We report that developmental competition between sympathetic neurons for survival is critically dependent on a sensitization process initiated by target innervation and mediated by a series of feedback loops. Target-derived nerve growth factor (NGF) promoted expression of its receptor TrkA in neurons and prolonged TrkA-mediated signals. NGF also controlled expression of brain derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4), which, through the receptor p75, can kill neighboring neurons with low retrograde NGF–TrkA signaling whereas neurons with high NGF–TrkA signaling are protected. Perturbation of any of these feedback loops disrupts the dynamics of competition. We suggest that three target-initiated events are essential for rapid and robust competition between neurons: sensitization, paracrine apoptotic signaling, and protection from such effects.
Keywords: comparative gene expression analysis
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| Overall design |
This experiment examine gene expression differences in superior cervical ganglia fro P0 bax null versus NGF-Bax double null animals. The Bax genotype was used in order to prevent the neuronal cell death normally observed in the NGF null animal.
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| Contributor(s) |
Deppmann CD, Mihalas S, Sharma N, Lonze BE, Niebur E, Ginty DD |
| Citation(s) |
18323418 |
| |
| Submission date |
Feb 12, 2008 |
| Last update date |
Jan 08, 2019 |
| Contact name |
David D Ginty |
| E-mail(s) |
[email protected]
|
| Organization name |
Johns Hopkins University School of Medicine
|
| Department |
Neuroscience
|
| Street address |
725 N. Wolfe St.
|
| City |
Baltimore |
| State/province |
MD |
| ZIP/Postal code |
21205 |
| Country |
USA |
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| Platforms (2) |
| GPL339 |
[MOE430A] Affymetrix Mouse Expression 430A Array |
| GPL340 |
[MOE430B] Affymetrix Mouse Expression 430B Array |
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| Samples (8)
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| GSM265434 |
SCG from P0 bax null mouse sample 1 moe430A |
| GSM265435 |
SCG from P0 bax null mouse sample 2 moe430A |
| GSM265437 |
SCG from P0 bax/ngf double null mouse sample 1 moe430A |
| GSM265438 |
SCG from P0 NGF/Bax double null mouse sample 2 moe430A |
| GSM265440 |
SCG from P0 Bax null mouse sample 1 moe430B |
| GSM265441 |
SCG from P0 Bax null mouse sample 2 moe430B |
| GSM265442 |
SCG from P0 NGF-Bax double null mouse sample 1 moe430B |
| GSM265443 |
SCG from P0 NGF-Bax double null mouse sample 2 moe430B |
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| Relations |
| BioProject |
PRJNA107953 |
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