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| Status |
Public on Jul 15, 2017 |
| Title |
Development of gene expression signatures for experimental lingual carcinogenesis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
To identification of gene expression profiling during lingual tumorigenesis, tongue cancer was induced by oral delivery of 4-nitroquinoline-1-oxide (4NQO) at a dose of 50mg/L for 16weeks in C57BL/6J female mice. Nine samples of lingual mucosa from 0th (encoded as C in experiment), 12th ((encoded as M in experiment) and 28th ((encoded as E in experiment) week which were supposed as normality, early stage and cancer during lingual tumorigenesis were harvested for microarray. 2339, 2539 and 2482 genes were significantly varied between M vs. C, E vs. M and E vs. C respectively.
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| Overall design |
Chemical carcinogen 4-nitroquinoline-1-oxide induced gene expression in C57BL/6J female mice was measured at 0th (C), 12th (M) and 28th (E) week after oral delivery of 4-nitroquinoline-1-oxide (4NQO) at a dose of 50mg/L. Three independent experiments were performed at each time (0th ,12th ,28th week) using lingual mucosa.
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| |
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| Contributor(s) |
Dai X, Liu H |
| Citation(s) |
30135512 |
| |
| Submission date |
Jul 14, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
XiaoMing Dai |
| E-mail(s) |
[email protected]
|
| Organization name |
The first affiliated hospital of Kunming Medical University
|
| Department |
The maxillofacial service of the department of plastic surgery,
|
| Street address |
293#,Xichang road
|
| City |
Kunming |
| State/province |
Yunnan |
| ZIP/Postal code |
650031 |
| Country |
China |
| |
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| Platforms (1) |
| GPL11202 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA394518 |
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